基本信息
浏览量:1
职业迁徙
个人简介
Our research asks how the RNA polymerase II transcriptional machinery and RNA processing factors work together to achieve coordinated synthesis and maturation of messenger RNA (mRNA). The coupling of transcription and processing to make mRNA’s accurately and efficiently is essential to the health of all cells and is corrupted in many diseases. To make a fully functional mRNA requires synthesis of a primary transcript by RNA polymerase II and maturation of the transcript by capping the 5’ end, removal of introns by splicing and adding a poly A tail at the 3’ end. A mature mRNA is "gift-wrapped" with binding proteins that direct its export from nucleus to cytoplasm. A center-piece of the molecular machinery that couples synthesis with processing and export of mRNA’s is the C-terminal domain or CTD, a signature feature of the largest subunit of RNA polymerase II. If this domain is removed, transcripts lose their identity as mRNA precursors. Many of the projects in our lab test the mRNA is made within a factory complex that comprises RNA polymerase II together with mRNA processing factors that bind to the CTD "landing pad".
研究兴趣
论文共 289 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Benjamin Erickson,Roman Fedoryshchak, Nova Fong,Ryan Sheridan, Keira Y. Larson, Anthony J. Saviola, Stephane Mouilleron,Kirk C. Hansen,Richard Treisman,David L. Bentley
crossref(2024)
Journal of Molecular Biologypp.168743-168743, (2024)
Alona Sosinsky,John Ambrose,William Cross,Clare Turnbull,Shirley Henderson,Louise Jones,Angela Hamblin,Prabhu Arumugam,Georgia Chan,Daniel Chubb,Boris Noyvert,Jonathan Mitchell,Susan Walker, Katy Bowman,Dorota Pasko, Marianna Buongermino Pereira,Nadezda Volkova,Antonio Rueda-Martin,Daniel Perez-Gil,Javier Lopez, John Pullinger,Afshan Siddiq,Tala Zainy, Tasnim Choudhury, Olena Yavorska,Tom Fowler,David Bentley,Clare Kingsley,Sandra Hing,Zandra Deans,Augusto Rendon,Sue Hill,Mark Caulfield,Nirupa Murugaesu
Kira Cozzolino,Lynn Sanford,Samuel Hunter,Kayla Molison,Benjamin Erickson,Taylor Jones, Meaghan C S Courvan,Deepa Ajit,Matthew D Galbraith,Joaquin M Espinosa,David L Bentley,Mary A Allen,Robin D Dowell,Dylan J Taatjes
bioRxiv : the preprint server for biology (2024)
Pascal Grobecker, Stefano Berri,John F. Peden, Kai-Jie Chow, Claire Fielding,Ivana Armogida,Helen Northen,David J. McBride,Peter J. Campbell,Jennifer Becq,Sarra L. Ryan,David R. Bentley,Christine J. Harrison,Anthony V. Moorman,Mark T. Ross,Martina Mijuskovic
crossref(2024)
BIO-PROTOCOLno. 18 (2023)
Genomics commercial opportunities from a scientific revolutionpp.3-14, (2023)
Claire Schwab,Ruth E. E. Cranston,Sarra L. L. Ryan,Ellie Butler,Emily Winterman,Zoe Hawking,Matthew Bashton,Amir Enshaei, Lisa J. J. Russell,Zoya Kingsbury,John F. F. Peden,Emilio Barretta,James Murray,Jude Gibson,Andrew C. C. Hinchliffe,Robert Bain,Ajay Vora,David R. R. Bentley,Mark T. T. Ross,Anthony V. V. Moorman,Christine J. J. Harrison
Cell genomicsno. 2 (2023): 100258-100258
Brandon Leonard,Steven N. Hart,Michael B. Burns,Michael A. Carpenter, Nuri A. Temiz,Anurag Rathore,Rachel I. Vogel,Jason B. Nikas,Emily K. Law,William L. Brown,Ying Li,Yuji Zhang, Matthew J. Maurer, Ann L. Oberg, Julie M. Cunningham, Viji Shridhar,Debra A. Bell, Craig April,David Bentley,Marina Bibikova,R. Keira Cheetham,Jian-Bing Fan,Russell Grocock,Sean Humphray,Zoya Kingsbury,John Peden, Jeremy Chien,Elizabeth M. Swisher,Lynn C. Hartmann,Kimberly R. Kalli,Ellen L. Goode,Hugues Sicotte,Scott H. Kaufmann,Reuben S. Harris
openalex(2023)
加载更多
作者统计
#Papers: 290
#Citation: 47261
H-Index: 101
G-Index: 217
Sociability: 8
Diversity: 0
Activity: 1
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn