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个人简介
Our research involves the elucidation of the structure, dynamics and function of proteins; including the role of intrinsically unfolded regions in regulating biological interactions. The major systems focus of our research is cardiovascular disease. In particular, we are interested in the function of the proteins that make up the thin filament of skeletal and cardiac muscle and regulate contraction; focusing on the calcium sensitive interactions between actin, tropomyosin, and troponin. We are presently studying the effects of drug binding, phosphorylation, acidosis and FHC mutations in the cardiac system. Our major tool is nuclear magnetic resonance spectroscopy, especially the use of multi-nuclear and multi-dimensional NMR techniques combined with the computational techniques of energy minimization and molecular dynamics to determine the structure of proteins in solution. We are also studying prion proteins in order to understand the mechanism of the conversion from the cellular to the Scrapie form; using NMR based metabolomic studies to diagnose human disease; and developing NMR methods for the study of the structure of membrane proteins.
研究兴趣
论文共 911 篇作者统计合作学者相似作者
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Journal of Biomolecular NMR (2024)
Vaidhvi Singh,Gail West,Claudio Fiocchi,Caryn E. Good,Jeffry Katz,Michael R Jacobs,Armand Earl Ko Dichosa,Chris Flask, Mathew Wesolowski, Cassidy McColl, Brandon Grubb,Sadia Ahmed,Nicholas C. Bank, Kavitha Thamma,Ilya Bederman,Bernadette Erokwu, Xinlin Yang,Mark S. Sundrud,Paola Menghini,Abigail Raffner Basson,Jessica Ezeji,Satish E Viswanath,Alida Veloo,David B. Sykes,Fabio Cominelli,Alex Rodriguez-Palacios
bioRxiv the preprint server for biology (2024)
Cancer Researchno. 6_Supplement (2024): 5270-5270
Bloodno. Supplement 1 (2024): 3293-3293
Graham Blake Parker, Justin Cheng,Louis Terriou,Johanna Strobl, Ayesha Iftikhar,Davide Nappi,Meng Pan, Pierre-Yves Sansen,Elisa Diral,Elena Maria Elli,Wilfried A Schroyens,David B. Sykes,Casey L. O'Connell, Caitlin M O'Neill
Bloodno. Supplement 1 (2024): 5551-5551
NATURE CELL BIOLOGYno. 4 (2024)
Lingli He,Ting Zhao, Wei Zhong Leong,Azeem Sharda,Christina Mayerhofer, Shenglin Mei, Gracia M. Bonilla,Juan Bautista Menendez-Gonzalez, Karin Gustafsson, Tsuyoshi Fukushima, Trine A. Kristiansen, Ji-Won Lee, Yanxin Xu,Bogdan Budnik,Ruslan Sadreyev,Zhixun Dou,David B. Sykes,David Scadden
Bloodno. Supplement 1 (2024): 1354-1354
Ioanna Tsea, Thale Kristin Olsen, Panagiotis Alkinoos Polychronopoulos,Conny Tümmler,David B. Sykes, Ninib Baryawno,Cecilia Dyberg
Cancersno. 24 (2024): 4162
Cancer Researchno. 6_Supplement (2024): 1396-1396
eLife (2024)
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作者统计
#Papers: 909
#Citation: 45858
H-Index: 93
G-Index: 193
Sociability: 8
Diversity: 3
Activity: 159
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