Dr. Lombard received his M.D. degree from Harvard Medical School, and he pursued his doctoral studies with Dr. Leonard Guarente at MIT, whose laboratory discovered the relationship between sirtuins and longevity in yeast. After Pathology residency, Dr. Lombard pursued his postdoctoral work in Dr. Frederick Alt’s laboratory. With Dr. Alt, Dr. Lombard studied the sirtuins SIRT3 and SIRT6, work supported by a K08 award from NIA/NIH. Dr. Lombard was the first to describe a central role for SIRT3 in regulating mitochondrial protein acetylation, in a paper cited >500 times according to Google Scholar. Subsequent studies have revealed that SIRT3 is a major player in regulating metabolism, the pro-longevity calorie restriction response, in tumor suppression, and cardioprotection; Dr. Lombard has contributed to several of these subsequent publications. Among Dr. Lombard’s most significant recent contributions have been describing SIRT6’s tumor suppressor function via repression of tumor cell metabolism, and novel aspects of mitochondrial regulation by SIRT5. His lab contributed to the discovery of SIRT5’s non-canonical catalytic activities. He was named a New Scholar in Aging of the Ellison Medical Foundation. He is currently the PI on an NIH R01 and a DoD grant focused on sirtuin biology, a member of the Aging Cell editorial board, and has participated in numerous NIH study sections.