Daniel J. Hicklin - Biologics Strategy—Oncology, Merck Research Laboratories

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Discovery of WTX-518, an IL-18 Pro-Drug That is Conditionally Activated Within the Tumor Microenvironment and Induces Regressions in Mouse Tumor Models

Kristin R. Morris,Heather Brodkin,Kyriakos Economides,Daniel J. Hicklin, Julie LePrevost, Celesztina Nagy-Domonkos,Christopher Nirschl, Andres Salmeron, Cynthia Seidel-Dugan, Cierra Spencer,Zoe Steuert,William M. Winston

CANCER RESEARCHno. 6 (2024)

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Abstract 4078: WTX-712, a conditionally active IL-21 INDUKINETM molecule, induces a strong anti-tumor phenotype through a differentiated mechanism

Jenna M. Sullivan, Pamela A. Aderhold,Heather R. Brodkin,Celesztina Nagy-Domonkos,Kyriakos Economides,Daniel J. Hicklin,Nesreen Ismail,Yuka Lewis, Cynthia Seidel-Dugan,William M. Winston,Andres Salmeron

Cancer Researchno. 6_Supplement (2024): 4078-4078

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955 INDUKINE™ Molecules Delivering Various Cytokines Utilize Unique Mechanisms of Action to Drive Anti-Tumor Efficacy in Murine Syngeneic Tumor Models

Christopher J Nirschl, Pamela Aderhold, Heather R Brodkin, Olivia G Donovan, Connor J Dwyer,Daniel J Hicklin, Cierra Spencer, Zoe Steuert, Jenna M Sullivan, William M Winston, Andres Salmeron

Regular and Young Investigator Award Abstracts (2024)

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WTX-712, a Conditionally Active IL-21 INDUKINETM Molecule, Induces a Strong Anti-Tumor Phenotype Through a Differentiated Mechanism

Jenna M. Sullivan, Pamela A. Aderhold, Heather R. Brodkin, Celesztina Nagy-Domonkos,Kyriakos Economides,Daniel J. Hicklin,Nesreen Ismail, Yuka Lewis, Cynthia Seidel-Dugan,William M. Winston, Andres Salmeron

CANCER RESEARCHno. 6 (2024)

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Abstract 4074: Discovery of WTX-518, an IL-18 Pro-Drug That is Conditionally Activated Within the Tumor Microenvironment and Induces Regressions in Mouse Tumor Models

Kristin R. Morris,Heather Brodkin,Kyriakos Economides,Daniel J. Hicklin, Julie LePrevost,Celesztina Nagy-Domonkos,Christopher Nirschl,Andres Salmeron,Cynthia Seidel-Dugan, Cierra Spencer,Zoe Steuert,William M. Winston

Cancer researchno. 6_Supplement (2024): 4074-4074

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Supplementary Figure 4 from Therapeutic Implications of a Human Neutralizing Antibody to the Macrophage-Stimulating Protein Receptor Tyrosine Kinase (RON), a c-MET Family Member

Jennifer M. O'Toole,Karen E. Rabenau,Kerri Burns, Dan Lu,Venkat Mangalampalli,Paul Balderes,Nicole Covino,Rajiv Bassi, Marie Prewett,Kimberly J. Gottfredsen,Megan N. Thobe, Yuan Cheng, Yiwen Li,Daniel J. Hicklin,Zhenping Zhu,Susan E. Waltz,Michael J. Hayman,Dale L. Ludwig,Daniel S. Pereira

crossref（2023）

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1074 PK/RO Modeling of WTX-124, a Tumor-Activated IL-2 Prodrug, Highlights the Potential for a Substantially Improved Therapeutic Index Compared to Other IL-2 Molecules

Christopher J Nirschl,Kyriakos Economides,Kristin Morris,Andres Salmeron,Daniel J Hicklin, Cynthia Seidel-Dugan,Kulandayan K Subramanian,Randi Isaacs, Sameer Chopra,Celesztina Domonkos

Regular and Young Investigator Award Abstracts (2023)

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Supplementary Video 1b from Targeted Anti–Vascular Endothelial Growth Factor Receptor-2 Therapy Leads to Short-term and Long-term Impairment of Vascular Function and Increase in Tumor Hypoxia

Marcela Franco,Shan Man,Limor Chen,Urban Emmenegger,Yuval Shaked,Alison M. Cheung,Allison S. Brown,Daniel J. Hicklin,F. Stuart Foster,Robert S. Kerbel

openalex（2023）

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Supplementary Figure 1 from Therapeutic Implications of a Human Neutralizing Antibody to the Macrophage-Stimulating Protein Receptor Tyrosine Kinase (RON), a c-MET Family Member

Jennifer M. O'Toole,Karen E. Rabenau,Kerri Burns, Dan Lu,Venkat Mangalampalli,Paul Balderes,Nicole Covino,Rajiv Bassi, Marie Prewett,Kimberly J. Gottfredsen,Megan N. Thobe, Yuan Cheng,Yiwen Li,Daniel J. Hicklin,Zhenping Zhu,Susan E. Waltz,Michael J. Hayman,Dale L. Ludwig,Daniel S. Pereira

crossref（2023）

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1059 Spatial analysis of tumor infiltrating lymphocyte populations in syngeneic mouse tumor models after treatment with IL-12 (mWTX-330) and IL-2 (WTX-124) INDUKINETM molecules

Christopher J Nirschl,Andres Salmeron,Zoe Steuert,Heather R Brodkin,Daniel J Hicklin,Cynthia Seidel-Dugan,William M Winston

Journal for ImmunoTherapy of Cancerno. Suppl 1 (2023)

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