The overall objective of Dr. Daniel Gonzalez’s research program is to optimize pharmacotherapeutic efficacy and safety through the use of clinical and experimental data, and the application of mathematical modeling and simulation techniques, with an emphasis in pediatric populations. This is first accomplished by characterizing the differences in pharmacokinetic (PK) and pharmacodynamic (PD) relationships across human development, elucidating and quantifying influential factors of drug disposition, and the degree of interindividual variability surrounding them. Assessment of such changes are then related to deviations in drug effects and overall patient outcomes. With such characterizations established, optimal dosing regimens are derived, with a clinical impact in patient populations for which evidence-based dosing recommendations are frequently absent. The Gonzalez Lab is currently focused on research in the following areas: Characterizing drug pharmacokinetics/pharmacodynamics in the pediatric population Studying the effect of obesity on pharmacokinetics and drug dosing in children and adolescents Evaluating drug-drug interactions in the pediatric population Use of real-world data to evaluate drug safety and efficacy Drug dosing individualization