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My research in Oxford has been based on the study of cardiac structure, function and metabolism in normal and diseased hearts using MRI/MRS. This has included developing techniques using high spatial and temporal resolution CINE imaging to assess heart function and localized phosphorus and carbon spectroscopy to monitor and investigate abnormalities of metabolism. I have recently been awarded a British Heart Foundation Senior Research Fellowship to further develop the technique of Dynamic Nuclear Polarization (DNP) for application to the study of cardiac metabolism in the human heart. A fundamental limitation of magnetic resonance is its low sensitivity, but the recently developed technique of DNP provides a practical method to gain up to 10,000-fold increases in sensitivity in molecules with an in vivo stability of approximately one minute. This has enabled visualization of 13C-labelled cellular metabolites in vivo and, more importantly, their enzymatic transformation into other species. This is an important development that could revolutionize spectroscopy using MR.
Research Interests
Papers共 280 篇Author StatisticsCo-AuthorSimilar Experts
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Atherosclerosispp.118599, (2024)
Ayaka Shinozaki, Juan D Sanchez-Heredia, Markus P Andersen, Mohsen Redda, Duy A Dang, Esben S S Hansen, Rolf F Schulte, Christoffer Laustsen,Damian J Tyler, James T Grist
Scientific reportsno. 1 (2024): 20591-20591
Anurag Choksey, Ryan D. Carter, Benjamin D. Thackray,Vicky Ball,Brett W. C. Kennedy, Lea Hong Tuan Ha,Eshita Sharma,John Broxholme,Marcos Castro-Guarda, Michael P. Murphy,Lisa C. Heather,Damian J. Tyler,Kerstin N. Timm
Sarah Birkhoelzer,Per Arvidsson, Mehrsa Jafarpour, John Henry, Jordan J McGing,Damian Tyler,Oliver Rider,Ladislav Valkovič,Jenny Rayner
NMR in biomedicinepp.e5206-e5206, (2024)
Frontiers in physiology (2024)
CHEMPHYSCHEMno. 18 (2023)
Magnetic resonance in medicineno. 4 (2023): 1598-1607
Elanor Hinton, Xue Min, Peter Stephenson, Sigridur Unnarsdottir,Oliver Rider,Damian Tyler,James Byrne, Camilla Easter,Hutan Ashrafian
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#Papers: 279
#Citation: 8499
H-Index: 53
G-Index: 83
Sociability: 7
Diversity: 0
Activity: 2
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