I am an internist-cardiovascular epidemiologist with a broad research and training portfolio whose efforts are now focused on population health improvement. I have been an active investigator in multiple NHLBI-funded cohort studies, including the Cardiovascular Health Study (CHS), the Multi-Ethnic Study of Atherosclerosis, the Coronary Artery Risk Development in Young Adult Study, and the Women’s Health Initiative, the Cohorts of Heart and Aging Research on Genomic Epidemiology (CHARGE), and the principal investigator of multiple grants funded by the NIH. The research has focused on a range of characteristics, including exercise, nutrition, diabetes, obesity, renal disease, mineral metabolism, developmental origins, women's health, drug safety, air pollution, and genetics and their associations with a wide-range of cardio-metabolic disease outcomes across the life cycle.