基本信息
浏览量:113
职业迁徙
个人简介
My cancer related research is focused on the molecular mechanisms underlying the progression from endometriosis to clear cell ovarian cancer. Endometriosis is a relatively common condition affecting approximately 10% of women of child bearing age and it is known from epidemiological studies that in a small proportion of these cases there is an increased incidence of clear cell ovarian cancer. Recent work has shown that mutations in Arid1a gene are strongly associated with clear cell ovarian cancer and my work focuses on determining the role of this gene in endometriosis and its possible progression to clear cell carcinoma. To that end, we use a model of murine endometriosis which we developed which we are using to test the effects of Arid1a ablation. We also carry out work using human tissues in vitro, in vivo and in retrospective genetics studies. I have other work focused on endothelial cell biology but with particular relevance to the behaviour and function of these cells in the reproductive tract. The female reproductive tract and the placenta provide physiological systems in which angiogenesis occurs on a regular basis. Understanding how this process is controlled under normal conditions gives insight into the basic biological mechanisms underlying angiogenesis which may be perturbed under pathological conditions and are also open to therapeutic intervention. Endothelial cells are also a critical part of the placenta and the way this tissue responds to oxidative stress during pregnancy is also of considerable interest. My work focuses on the molecular mechanisms underlying the behaviour of these cells and I use a range of techniques including gene array analysis, RNAi-mediated knock-down, cellular and in vivo models. My work on understanding and manipulating angiogenesis is of direct relevance to solid tumour growth.
研究兴趣
论文共 281 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
American Journal of Obstetrics and Gynecologyno. 1 (2024): S560-S561
Placenta (2023): e35-e35
Nature Microbiologyno. 12 (2023): 2338-2348
American Journal of Obstetrics and Gynecologyno. 5 (2023)
M. Fejzo,N. Rocha,I. Cimino, S. M. Lockhart,C. J. Petry,R. G. Kay,K. Burling,P. Barker, A. L. George, N. Yasara,A. Premawardhena, S. Gong, E. Cook,D. Rimmington,K. Rainbow, D. J. Withers, V. Cortessis,P. M. Mullin, K. W. MacGibbon, E. Jin, A. Kam, A. Campbell,O. Polasek, G. Tzoneva,F. M. Gribble,G. S. H. Yeo,B. Y. H. Lam,V. Saudek,I. A. Hughes,K. K. Ong,J. R. B. Perry, A. Sutton Cole, M. Baumgarten,P. Welsh,N. Sattar,G. C. S. Smith,D. S. Charnock-Jones,A. P. Coll,C. L. Meek,S. Mettananda, C. Hayward,N. Mancuso,S. O’Rahilly
Natureno. 7996 (2023): 760-767
STAR Protocolsno. 3 (2023)
American Journal of Obstetrics and Gynecology (2023)
加载更多
作者统计
#Papers: 281
#Citation: 17568
H-Index: 68
G-Index: 129
Sociability: 7
Diversity: 3
Activity: 45
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn