Daniel Rodriguez Gutierrez

Human sex development relies on differentiation of the gonads, in which the Sertoli and granulosa cells play a key role respectively for men and women. Many differences of sex development (DSD) are due to alteration of these two cell types. The study of the mechanisms underlying these conditions is crucial for optimal clinical management of DSDs. The primary collection of these cells is painful for the patient and their culture extremely difficult due to their short lifespan and the loss of their unique characteristics when cultured in vitro. Additionally, the available cell models cannot reproduce the mechanism leading to disease in single DSD patients. Human induced-pluripotent stem cells (iPSCs) are developing as exciting cell sources for applications in regenerative medicine and dru