Dr. Matthews develops medical devices in particular those which use photon or electromagnetic spectrum-based technology. Current interests are focused on developing a non-invasive heart monitor for cardiac decompensation.

Dr. Matthews leads a multi-directorate center within Livermore whose mission is to develop medical devices in collaboration with industry. Current projects and those already successfully transferred to industry include: an opto-acoustic recanalization device for treating ischemic stroke; a miniature x-ray source which is mounted on a microcatheter and used to treat coronary artery restenosis; micropower impulse radar for numerous medical diagnostics, including: differentiating hemorrhagic vs. ischemic stroke; an implantable, continuous-glucose monitor; and ultra-short-pulse laser microsurgery devices.