In 2002, I was awarded substantial EPSRC funding to establish and direct the Life Science Interface Doctoral Training Programme. This innovative and four-year DPhil programme was designed and individually tailored to provide comprehensive training in the application of techniques, taken from the mathematical and physical sciences, to cutting-edge research in the biomedical and life sciences. Following the success of the initial programme, the Rex Richards Building now houses our Doctoral Training Centre in the heart of the University's South Parks Road science campus. Collectively, over £60 million in RCUK funding and over £10 million from industrial contributors has allowed us to offer a range of six focused programmes: Systems Biology, Systems Approaches to Biomedical Science, Synthetic Biology, Interdisciplinary Bioscience, Synthesis for Biology and Medicine, and Biomedical Imaging. Around forty studentships are available annually, across a range of interdisciplinary areas and including a small number available to international students. Over five hundred students have enrolled in a DTC programme to date; graduates have gone on to successful careers in industrial and academic research, with a large proportion undertaking entrepreneurial activities.