The overall goal of her research is to develop therapeutic and prevention strategies to respond to global infectious disease pandemics: HIV, TB, and COVID-19. Antiretroviral therapy—for prevention or treatment—is one of the greatest successes in medicine, yet we have not fully used it to eliminate HIV or its complications such as tuberculosis (TB). In the first SEARCH study, Dr. Havlir and her team showed that a multi-disease, patient-centered approach to HIV testing and treatment reduced HIV incidence, HIV-associated tuberculosis and HIV-associated mortality, while improving population-level control of hypertension in a NIH-funded 320,000-person cluster-randomized study in rural East Africa. She continues towards her goal to accelerate the end of AIDS through the SEARCH-Sapphire study, which is testing an innovative “Community Precision Health” strategy which uses a multi-disease approach to incorporate AI and machine learning into delivery systems on a path to universal healthcare.