Rick Grobbee has been a (principal) investigator in many large-scale epidemiologic studies and randomized intervention trials relating to the prevention and treatment of cardiovascular, cardiometabolic, and cardiorenal disease. In addition he works on the principles and methods of treatment research, trial design and (big-) data analysis. In the Netherlands he was member of the supervisory board of the Netherlands Heart Foundation and acted in several roles in committees of the National Research Council (ZonMW). He is chair of the Dutch National Research Agenda (NWA) route "Prevention". He has been listed in the top 100 global most influential biomedical researchers (Eur J Clin Invest 2013 Dec;43(12):1339-65) and has consistently been ranked as highly cited author by Web of Science over the last decades.