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The Moody laboratory seeks to understand how human T cells control outcomes of infection and autoimmune disease. CD1 proteins are a family of evolutionarily conserved antigen presenting molecules that bind lipid antigens for presentation to T cells. Using mass spectrometry to study the lipid content of the cell wall of M. tuberculosis, we have discovered of lipid ligands for CD1a, CD1b, CD1c and CD1d proteins. Using these model antigens, we are studying the cellular mechanisms of lipid loading onto CD1 proteins in dendritic cells and the roles of Toll-like receptors in promoting cellular antigen presentation. Recently, we have reported the first studies of CD1a, CD1b and CD1c tetramers in humans. Through the Department of Medicine at the Brigham and Women’s hospital, we are using these lipids and tetramers to study the function of CD1-restricted T cells in healthy humans and in disease states. Recent studies have identified new populations of human T cells, including IL-22 secreting CD1a autoreactive T cells and germline encoded mycolyl reactive (GEM) T cells. Further, we have reported new mechanisms of T cell recognition of self lipids whereby TCRs take unexpected binding positions on CD1 lipid complexes. Last, we have developed a program to identify the molecular mechanisms of virulence by the pathogen M. tuberculosis. This program had uncovered mechanisms by which this intracellular pathogen remodels its growth niche in macrophages, converting phagolysosomes from killing compartments into lipid-rich feeding compartments. Our overall goal is to develop a basic understanding of the cellular mechanisms that allow T cells to discriminate among self and foreign antigens, so that these antigens and adjuvants can be developed as immunomodulatory agents and vaccines for treatment of patients.
研究兴趣
论文共 274 篇作者统计合作学者相似作者
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Tan-Yun Cheng, T Praveena, Srinath Govindarajan,Catarina F Almeida, Daniel G Pellicci, Wellington C Arkins,Ildiko Van Rhijn,Koen Venken,Dirk Elewaut,Dale I Godfrey,Jamie Rossjohn,D Branch Moody
Proceedings of the National Academy of Sciences of the United States of Americano. 34 (2024): e2321686121-e2321686121
Journal of biological chemistry/The Journal of biological chemistrypp.107511-107511, (2024)
Elizabeth Bryan,Jessica E. Teague, Sezin Eligul, Wellington C. Arkins,D. Branch Moody,Rachael A. Clark,Ildiko Van Rhijn
JOURNAL OF INVESTIGATIVE DERMATOLOGYno. 4 (2024): 833-843.e3
Victor E. Nieto-Caballero, Josephine F. Reijneveld, Angel Ruvalcaba, Gabriel Innocenzi, Nalin Abeydeera, Samira Asgari,Kattya Lopez,Sarah K. Iwany, Yang Luo,Aparna Nathan,Daniela Fernandez-Salinas,Marcos Chinas,Chuan-Chin Huang,Zibiao Zhang,Segundo R. Leon,Roger I. Calderon,Leonid Lecca, Jonathan M. Budzik,Megan Murray,Ildiko Van Rhijn,Soumya Raychaudhuri,D. Branch Moody,Sara Suliman,Maria Gutierrez-Arcelus
PLOS geneticsno. 6 (2024): e1011313-e1011313
Journal of Lipid Researchno. 7 (2024): 100533-100533
Melissa Bedard,Sanne van der Niet,Elliott M. Bernard,Gregory Babunovic,Tan-Yun Cheng,Beren Aylan,Anita E. Grootemaat,Sahadevan Raman,Laure Botella,Eri Ishikawa,Mary P. O'Sullivan,Jacob A. Mayfield,Seonadh O'Leary,Jeffrey Buter,Adriaan J. Minnaard,Sarah M. Fortune,Leon O. Murphy,Daniel S. Ory,Joseph Keane,Sho Yamasaki,Maximiliano G. Gutierrez,Nicole van der Wel,D. Branch Moody
bioRxiv the preprint server for biology (2023)
European journal of immunologyno. 10 (2023): e2250333-e2250333
Current Opinion in Immunology (2023): 102339
JOURNAL OF BIOLOGICAL CHEMISTRYno. 2 (2023)
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#Papers: 275
#Citation: 12083
H-Index: 58
G-Index: 104
Sociability: 7
Diversity: 3
Activity: 206
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