基本信息
浏览量:119
职业迁徙
个人简介
Franzini-Armstrong's primary interest in science has been the disposition of membranes and macromolecular complexes that are responsible for excitation-contraction (e-c) coupling in cardiac and skeletal muscles.She engaged in four main phases of structural work in terms of her career. Her first phase focused on calcium cycling and, especially, on defining the distribution and nature of the two membrane systems involved in this specific type of cycling. Franzini-Armstrong's second phase discovered the location of channels that release calcium during muscle activation. She also demonstrated that in muscles that can engage in high activity rates, a limiting factor is the density of the pump protein and not the density of calcium release channels.Furthermore, the third phase of Franzini-Armstrong's structural work recognized the relationship between the L type calcium channels of the plasmalemma and T tubules in cardiac and skeletal muscles. Specifically, she worked with CaV channels or dihydropyridine receptors (DHPRs) and the calcium release channels of the sarcoplasmic reticulum (RyRs).Her fourth phase, which continues to be her current interest, is the supramolecular complex that enables several molecules located in the sarcoplasmic reticulum that regulate calcium release to interact with one another. In her current work, Franzini-Armstrong continues to utilize structural approaches in order to better comprehend the different interactions between molecules.
研究兴趣
论文共 184 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
EUROPEAN JOURNAL OF TRANSLATIONAL MYOLOGYno. 1 (2024)
Frontiers in physiology (2022)
Proceedings of the National Academy of Sciencesno. 19 (2022)
Silverio Perrotta,Domenico Roberti,Debora Bencivenga,Paola Corsetto,Katie A. O'Brien,Martina Caiazza,Emanuela Stampone,Leanne Allison,Roland A. Fleck,Saverio Scianguetta,Immacolata Tartaglione,Peter A. Robbins,Maddalena Casale,James A. West,Clara Franzini-Armstrong,Julian L. Griffin,Angela M. Rizzo,Antonio A. Sinisi,Andrew J. Murray,Adriana Borriello,Federico Formenti,Fulvio Della Ragione
NEW ENGLAND JOURNAL OF MEDICINEno. 9 (2020): 835-844
加载更多
作者统计
#Papers: 182
#Citation: 9340
H-Index: 55
G-Index: 94
Sociability: 6
Diversity: 0
Activity: 0
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn