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Research
Research is primarily focused on understanding how eukaryotic cells maintain their proteins folded and functional by mechanistic studies of the cellular protein homeostasis (proteostasis) system.
Breakdown of the proteostasis system has severe consequences for the organism and results in the accumulation of toxic misfolded and aggregated proteins. Strikingly, protein aggregates are found in the brains of individuals with neurodegenerative disease, e.g. Alzheimer’s and Parkinson’s and is linked to disease progression. Furthermore, cancer cells with its high growth rates, genetic instability and stressful tumor environments accumulate misfolded and aggregated proteins. The age-related decline of physiology is also linked to protein misfolding suggesting a connection between age-induced decline and impairment of the proteostasis system. Understanding the molecular mechanisms that maintain cellular proteins folded and functional is a fundamental challenge in the biological sciences and is crucial for the development of new strategies to combat disease and aging.
Research is primarily focused on understanding how eukaryotic cells maintain their proteins folded and functional by mechanistic studies of the cellular protein homeostasis (proteostasis) system.
Breakdown of the proteostasis system has severe consequences for the organism and results in the accumulation of toxic misfolded and aggregated proteins. Strikingly, protein aggregates are found in the brains of individuals with neurodegenerative disease, e.g. Alzheimer’s and Parkinson’s and is linked to disease progression. Furthermore, cancer cells with its high growth rates, genetic instability and stressful tumor environments accumulate misfolded and aggregated proteins. The age-related decline of physiology is also linked to protein misfolding suggesting a connection between age-induced decline and impairment of the proteostasis system. Understanding the molecular mechanisms that maintain cellular proteins folded and functional is a fundamental challenge in the biological sciences and is crucial for the development of new strategies to combat disease and aging.
研究兴趣
论文共 63 篇作者统计合作学者相似作者
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Michela Ciccarelli,Claes Andreasson
JOURNAL OF MOLECULAR BIOLOGYno. 20 (2024)
Nature Communicationsno. 1 (2024): 1-20
Irene Álvarez-Guerra, Emma Block,Filomena Broeskamp, Sonja Gabrijelčič, Terence Infant,Ana de Ory,Lukas Habernig,Claes Andréasson,Tim P Levine,Johanna L Höög,Sabrina Büttner
Developmental cellno. 6 (2024): 759-775.e5
Melania Minoia, Jany Quintana-Cordero, Katharina Jetzinger,Ilgin Eser Kotan,Kathryn Jane Turnbull,Michela Ciccarelli,Anna E. Masser, Dorina Liebers, Eloïse Gouarin, Marius Czech,Vasili Hauryliuk,Bernd Bukau,Günter Kramer,Claes Andréasson
Nature communicationsno. 1 (2024)
Jaroslaw Marszalek, Paolo De Los Rios,Douglas Cyr,Matthias P. Mayer,Vasista Adupa,Claes Andreasson, Gregory L. Blatch,Janice E. A. Braun,Jeffrey L. Brodsky,Bernd Bukau,J. Paul Chapple,Charlotte Conz,Sebastien Dementin,Pierre Genevaux,Olivier Genest,Pierre Goloubinoff,Jason Gestwicki,Colin M. Hammond,Justin K. Hines,Koji Ishikawa, Lukasz A. Joachimiak, Janine Kirstein, Krzysztof Liberek, Dejana Mokranjac, Nadinath Nillegoda, Carlos H. I. Ramos,Mathieu Rebeaud, David Ron,Sabine Rospert, Chandan Sahi, Reut Shalgi, Bartlomiej Tomiczek, Ryo Ushioda, Elizaveta Ustyantseva, Yihong Ye, Maciej Zylicz,Harm H. Kampinga
Irene Álvarez-Guerra, Emma Block,Filomena Broeskamp, Sonja Gabrijelčič,Ana de Ory,Lukas Habernig,Claes Andréasson,Tim P. Levine,Johanna L. Höög,Sabrina Büttner
bioRxiv (Cold Spring Harbor Laboratory) (2023)
FRONTIERS IN MOLECULAR BIOSCIENCES (2023): 1155521-1155521
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作者统计
#Papers: 62
#Citation: 1845
H-Index: 25
G-Index: 41
Sociability: 5
Diversity: 3
Activity: 12
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