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职业迁徙
个人简介
A primary area of focus in my laboratory is the relationship between age-related loss of steroid hormones and the development of AD. For example, our research with postmortem human brain has helped to identify testosterone loss in aging men as a risk factor for AD. In rodent models, we observe that depletion of androgens accelerates development of AD-like neuropathology and increases neuronal vulnerability to toxic insult. Cell culture studies continue to identify the relevant underlying mechanisms for these androgen effects, including investigation of classic genomic actions (e.g., regulation of genes such as neprilysin) as well as activation of rapid cell signaling pathways (e.g., MAPK/ERK, CREB, PKC). In ongoing translational studies, we are building upon our basic science advances to develop specific therapeutic interventions that selectively activate protective androgen pathways (e.g., synthetic testosterone mimetics). Using this general research strategy, we are pursuing conceptually parallel basic science and translational projects to evaluate the interactions between estrogen and progesterone actions in the regulation of neurodegenerative cascades associated with AD.
研究兴趣
论文共 139 篇作者统计合作学者相似作者
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Cassandra J McGill,Amy Christensen,Wenjie Qian,Max A Thorwald, Jose Godoy Lugo, Sara Namvari, Olivia S White,Caleb E Finch,Bérénice A Benayoun,Christian J Pike
bioRxiv : the preprint server for biology (2024)
Scientific reportsno. 1 (2024): 15873-15873
Alexandra N. Demetriou, Kristina Shkirkova,Hongqiao Zhang,Saman Sizdahkhani, Manuel F. Morales, Alberto De La Isla, Lei Zhao,Arnold Diaz, Max Thorwald, José A. Godoy-Lugo, Baosen Zhou, Nathan Zhang,Andrew Li,Wendy J. Mack, Constantinos Sioutas,Christian J. Pike, William J. Mack
Strokeno. Suppl_1 (2024)
Saman Sizdahkhani,Kristina Shkirkova,Krista Lamorie-Foote, Hongquiao Zhang, Lifu Zhao,Arnold Diaz,Constantinos Sioutas,Caleb Finch,Christian Pike,William Mack
Neurosurgeryno. Supplement_1 (2024): 127-127
bioRxiv the preprint server for biology (2024)
Frontiers in Aging Neuroscience (2024)
Kristina Shkirkova,Alexandra N. Demetriou,Saman Sizdahkhani,Krista Lamorie-Foote,Hongqiao Zhang, Manuel Morales, Selena Chen, Lifu Zhao,Arnold Diaz,Jose A. Godoy-Lugo, Beryl Zhou,Nathan Zhang,Andrew Li,Wendy J. Mack,Constantinos Sioutas,Max A. Thorwald,Caleb E. Finch,Christian Pike,William J. Mack
STROKEno. 4 (2024): 1090-1093
Alexandra N. Demetriou, Selena Chen,Kristina Shkirkova,Hongqiao Zhang,Krista Lamorie-Foote, Isaiah Becerra, Lifu Zhao,Max A. Thorwald,Jose A. Godoy-Lugo,Wendy J. Mack,Constantinos Sioutas,Caleb E. Finch,Christian Pike,William J. Mack
Aging Cell (2024)
Max Thorwald,Jose A Godoy-Lugo,Gilberto Garcia,Justine Silva, Minhoo Kim,Amy Christensen,Wendy J Mack,Elizabeth Head,Peggy A O'Day, Berenice Anath Benayoun,Todd E Morgan,Christian J Pike,Ryo Higuchi-Sanabria,Henry Jay Forman,Caleb E Finch
bioRxiv : the preprint server for biology (2024)
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作者统计
#Papers: 139
#Citation: 10768
H-Index: 57
G-Index: 103
Sociability: 6
Diversity: 0
Activity: 1
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