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个人简介
Our lab, Genome Editing Lab (GEL), is interested in understanding the biological importance of the thousands of GE enzymes cataloged in microbial genome databases. Through modern bioinformatics tools, we systematically classify the sequences and associate them with the biochemical functions. This study should lead us to identification of the GE enzymes with enhanced function but lower off-target effects.
In addition, we apply the GE technologies as a tool of synthetic biology. In plant system, we showed that plant genome can be edited in non-GMO way. In other words, without using DNA encoding for the GE enzymes and sgRNA, we could directly introduce pre-assembled ribonucleoproteins (RNP) to plant nucleus, edit genomes and regenerate whole plants.
In addition, we apply the GE technologies as a tool of synthetic biology. In plant system, we showed that plant genome can be edited in non-GMO way. In other words, without using DNA encoding for the GE enzymes and sgRNA, we could directly introduce pre-assembled ribonucleoproteins (RNP) to plant nucleus, edit genomes and regenerate whole plants.
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论文共 82 篇作者统计合作学者相似作者
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Sunmee Choi,Min Kyoung You, Yun-A Jeon, Jaebok Lee, Jinhwa Kim,Young Jin Park, Jeongmo Kim,Jongjin Park,Jae Kwang Kim,Sunghwa Choe
GEN biotechnologyno. 3 (2023): 219-227
Research Square (Research Square) (2022)
crossref(2022)
Sunghwa Choe, Kenneth A. Feldmann
Transgenic Plant Researchpp.57-74, (2021)
Park, Jongjin, Yoon, Jiyoung,Kwon, Daekee,Han, Mi-Jung, Choi, Sunmee, Park, Slki,Lee, Junghyuk, Lee, Kiwook, Lee, Jaehwan,Lee, Seunghee,Kang, Kyung-Sun,Choe, Sunghwa
Scientific Reportsno. 1 (2021): 1-9
Puna Maya Maharjan, Jinyeong Cheon, Jiyun Jung, Haerim Kim, Jaewon Lee, Minjeong Song,Gi Uk Jeong,Youngchan Kwon,Byoungshik Shim,Sunghwa Choe
VACCINESno. 9 (2021): 992-992
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