Charlotte East - Astex Pharmaceuticals

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论文共 16 篇作者统计合作学者相似作者

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Abstract 7073: Integrating Fragment-Based Crystallographic Screening with Dtag-Protac Degradation and Genetic Rescue to Explore the Function of Eif4e

Paul A. Clarke,Swee Y. Sharp,Marianna Martella,Christopher I. Milton,Charlotte East,Mladen Vinkovic,Nicola Wallis,George Ward,Caroline Richardson, Andrew Woodhead

CANCER RESEARCHno. 6 (2024)

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Targeting MAPK-driven Tumors Via Inhibition of MAP2K4

Mark Wade,Emiliano Tamanini, Mathieu Unbekandt,Nicola Wallis,John Lyons,Joanne Munck, Andrew Woodhead,Patrick Schopf, Jessie Stow,Charlotte East, Mellissa Clark, Jeffrey St. Denis,Puja Pathuri

CANCER RESEARCHno. 6 (2024)

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Abstract 5902: Targeting MAPK-driven Tumors Via Inhibition of MAP2K4

Mark Wade,Emiliano Tamanini,Mathieu Unbekandt,Nicola Wallis,John Lyons,Joanne Munck,Andrew Woodhead,Patrick Schopf, Jessie Stow,Charlotte East, Mellissa Clark,Jeffrey St. Denis,Puja Pathuri

Cancer Research（2024）

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Protein Engineering Enables a Soakable Crystal Form of Human CDK7 Primed for High-Throughput Crystallography and Structure-Based Drug Design

Manjeet Mukherjee,Philip J. Day, Duncan Laverty, Juan A. Bueren-Calabuig,Andrew J. Woodhead,Charlotte Griffiths-Jones, Steve Hiscock,Charlotte East, Susan Boyd,Marc O'Reilly

STRUCTUREno. 8 (2024)

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Abstract A142: Fragment Based Discovery of Inhibitors of the Eif4e:Eif4g Interaction

Caroline J Richardson, Mladen Vincovic,Charlotte East,Nicola Wallis,George Ward, Andrew Woodhead

Molecular Cancer Therapeuticsno. 12_Supplement (2023)

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Abstract A110: Identifying Sensitive Patient Populations for CDK7 Inhibitors Using Cell Panel Screens and Bioinformatic Approaches

Keisha Hearn,Maria Ahn,Luke Bevan,Jessica Brothwood,Charlotte East, Anna Esteve-Arenys,Lynsey Fazal,Christopher Hindley, Sabrina James,Justyna Kucia-Tran,John Lyons,Joanne Munck,Harpreet Saini,Mathieu Unbekandt,Dhaval Varshney,Steve Wagner, Andrew Woodhead,Nicola Wallis

Molecular Cancer Therapeuticsno. 12_Supplement (2023)

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X-ray Screening of an Electrophilic Fragment Library and Application Toward the Development of a Novel ERK 1/2 Covalent Inhibitor

Jeffrey D. St Denis,Gianni Chessari,Anne Cleasby,Benjamin D. Cons,Suzanna Cowan,Samuel E. Dalton,Charlotte East,Christopher W. Murray,Marc O'Reilly,Torren Peakman, Magdalini Rapti, Jessie L. Stow

Journal of Medicinal Chemistry（2022）

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Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor

Emiliano Tamanini,Shin Miyamura,Ildiko M. Buck,Benjamin D. Cons,Lee Dawson,Charlotte East,Takashi Futamura, Shintaro Goto,Charlotte Griffiths-Jones,Tetsuya Hashimoto,Tom D. Heightman,Shunpei Ishikawa, Hideki Ito,Yosuke Kaneko, Tatsuya Kawato,Kazumi Kondo,Naoki Kurihara, James M. McCarthy,Yukiko Mori,Tsuyoshi Nagase,Yuichiro Nakaishi,Judith Reeks, Akimasa Sato,Patrick Schopf,Kuninori Tai, Taichi Tamai,Dominic Tisi,Alison J. -A. Woolford

ACS Medicinal Chemistry Letters（2022）

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