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个人简介
My scientific career has largely focused on developing an atomic-level understanding of a model cytoskeletal system, the kinesin molecular motor which transports cargo along microtubules. While my Ph.D. work emphasized X-ray crystallography and EPR spin-labeling techniques as applied to the kinesin system, my more recent work has turned towards advancing cryo-electron microscopy techniques to the point where atomic-level features can be obtained for systems such as cytoskeletal filaments. These efforts led to my recent synthesis, using cryo-electron microscopy (cryo-EM) and X-ray crystallography information, of an atomic-level model for kinesin’s ATP-sensing machinery in its active form, which is only assumed following microtubule attachment. This discovery led to a simple and intuitive “seesaw” mechanism describing how ATP binding leads to force generation in the microtubule-attached motor. My laboratory's research interests are rapidly expanding to include numerous other filament-related molecular machines, such the myosin molecular motor that powers muscle movement, and the fascinating endoflagellum that spirochete bacteria to convert their bodies into pathogenic 'drilling machines'.
研究兴趣
论文共 68 篇作者统计合作学者相似作者
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Science Advancesno. 6 (2024)
Communications chemistryno. 1 (2024): 164-164
Nature communicationsno. 1 (2024)
Journal of Biological Chemistryno. 3 (2023): 104196-S647
bioRxiv (2022)
The Journal of biological chemistry (2021): 100337-100337
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作者统计
#Papers: 67
#Citation: 1907
H-Index: 27
G-Index: 43
Sociability: 5
Diversity: 0
Activity: 0
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