Professor Chan is specialized in living donor liver transplantation, and the surgical management of liver, pancreatic and biliary cancer. He is an expert in advanced liver surgery, and is renowned for integrating transplant knowledge and operative techniques into surgical resection of advanced cancer. He is internationally recognized for his pioneering work in Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS). He performed the world-first pediatric ALPPS for hepatoblastoma in 2013, and has accrued one of the largest personal experience in ALPPS for hepatocellular carcinoma.