Caroline’s research has focused on understanding the role of both genetic and epigenetic variation in development and disease. Her group uses population-based approaches to study epigenetic information as a biomarker of exposure and a predictor of disease. She has developed and applied causal analysis methods to understand the role of epigenetic processes as disease mechanisms and has led studies investigating the genetic architecture of DNA methylation variation. Her research spans multiple clinical areas from perinatal health to cancer and includes the application of epigenetic biomarkers in disease prevention and prognosis. Caroline continues to pursue a part time research role at the University of Bristol where she is a Programme Lead in the MRC Integrative Epidemiology Unit, Principal Investigator of the Cancer Research UK-funded Integrative Cancer Epidemiology Programme and Co-Director of the Wellcome 4-Year PhD Programme in Molecular, Genetic & Lifecourse Epidemiology.