Dr. Burke enjoys patient care, medical education and research, particularly in the area of colorectal polyp and cancer prevention. She is internationally known for her work in the polyposis syndromes and is the Director of the Center for colon polyp and cancer prevention and has been awarded research grants from the National Cancer Institute, American College of Gastroenterology, and Industry to name a few, to study the effects of chemopreventive agents on the prevention of intestinal neoplasia.

She is the author of numerous peer reviewed manuscripts, abstracts, book chapters, and is a frequent reviewer for many digestive disease journals.

She has served as a committee member, or chairperson in the American College of Gastroenterology, American Society of Gastrointestinal Endoscopy and is currently on the Board of Trustees for the American College of Gastroenterology.