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职业迁徙
个人简介
Breast cancer is a prevalent disease with known clinical and molecular diversity. To address these challenges, my research team uses a multidisciplinary approach based upon genomics, genetics, cancer biology, bioinformatics, epidemiology, and clinical research to improve the outcomes of cancer patients. A major contribution of mine has been the discovery of the intrinsic subtypes of breast cancer. We demonstrated that breast cancers can be divided into at least five molecular subtypes using the “PAM50” assay, with my lab focusing particular attention on the Basal-like subtype, which represents ~80% of Triple Negative Breast Cancers. In addition, we have translated these molecular classifications into the human population; specifically, by using the Carolina Breast Cancer Study (CBCS), we have found that young African American (AA) women are diagnosed with Basal-like Breast Cancers approximately twice as often as their Caucasian counterparts. These results provide a partial explanation of the racial outcomes disparity in the USA between AAs and Caucasians; however, additional studies are needed and are an emphasis of our ongoing research.
Our main research focus includes identifying the drivers of metastatic disease, determining the role of the adaptive immune system in breast tumor progression, and improving therapeutic targeting of TNBC/Basal-like tumors. We use a multitude of experimental and computational approaches, including RNA-sequencing (RNAseq), single-cell approaches, proteomics, DNA exome and whole genome sequencing, cell culture, and mouse models. We use these approaches to discover the causative events of each molecular subtype in human tumors and then model these events in cell lines and mouse models where we can investigate tumor biology and immune system interactions. All of these genomic studies generate large volumes of data, and thus a significant portion of my lab is devoted to computational approaches to use these multi-omics data to develop statistical predictors of tumor responsiveness and long-term patient outcomes.
Our main research focus includes identifying the drivers of metastatic disease, determining the role of the adaptive immune system in breast tumor progression, and improving therapeutic targeting of TNBC/Basal-like tumors. We use a multitude of experimental and computational approaches, including RNA-sequencing (RNAseq), single-cell approaches, proteomics, DNA exome and whole genome sequencing, cell culture, and mouse models. We use these approaches to discover the causative events of each molecular subtype in human tumors and then model these events in cell lines and mouse models where we can investigate tumor biology and immune system interactions. All of these genomic studies generate large volumes of data, and thus a significant portion of my lab is devoted to computational approaches to use these multi-omics data to develop statistical predictors of tumor responsiveness and long-term patient outcomes.
研究兴趣
论文共 992 篇作者统计合作学者相似作者
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Aranzazu Fernandez-Martinez,Mattia Rediti,Gong Tang,Tomás Pascual,Katherine A Hoadley,David Venet,Naim U Rashid,Patricia A Spears,Md N Islam,Sarra El-Abed,Judith Bliss,Matteo Lambertini,Serena Di Cosimo, Jens Huobe,David Goerlitz, Rong Hu,Peter C Lucas,Sandra M Swain,Christos Sotiriou,Charles M Perou,Lisa A Carey
JAMA oncologyno. 5 (2024): 603-611
Min-Guk Cho,Rashmi J. Kumar, Chien-Chu Lin,Joshua A. Boyer,Jamshaid A. Shahir,Katerina Fagan-Solis,Dennis A. Simpson,Cheng Fan, Christine E. Foster, Anna M. Goddard, Lynn M. Lerner, Simon W. Ellington,Qinhong Wang,Ying Wang,Alice Y. Ho,Pengda Liu,Charles M. Perou,Qi Zhang,Robert K. McGinty,Jeremy E. Purvis,Gaorav P. Gupta
Cancer Researchno. 7_Supplement (2024)
Natalia Lorman-Carbo,Olga Martinez-Saez,Aranzazu Fernandez-Martinez,Patricia Galvan,Nuria Chic,Isabel Garcia-Fructuoso,Adela Rodriguez,Raquel Gomez-Bravo,Francesco Schettini,Paula Blasco,Oleguer Castillo,Blanca Gonzalez-Farre,Barbara Adamo,Maria Vidal,Montserrat Munoz,Charles M. Perou,Marcos Malumbres,Joaquin Gavila,Tomas Pascual,Aleix Prat,Fara Braso-Maristany
Scientific reportsno. 1 (2024): 16030-16030
Daniel G. Stover,Roberto Salgado, Oleksander Savenkov, Karla Ballman, Erica L. Mayer,Mark Jesus M. Magbanua,Sherene Loi, Mark Vater, Kristyn Glover, Mark Watson, Yujia Wen,W. Fraser Symmans,Charles Perou,Lisa A. Carey, Ann H. Partridge,Hope S. Rugo
NPJ BREAST CANCERno. 1 (2024)
Cancer Researchno. 9_Supplement (2024): PO2-15
Yash Agrawal,Aranzazu Fernandez-Martinez,Miguel Gil-Gil,Christoph Zielinski,Manuel Ruíz- Borrego,Eva Ciruelos,Montserrat Muñoz,Mireia Margelí,Begoña Bermejo,Antonio Antón,Zsuzsanna Kahan,Tibor Csöszi,José L Alonso-Romero,Jose Angel García-Sáenz,Pedro Sánchez-Rovira,Elena Álvarez,J. Ignacio Chacón,Santiago González-Santiago,César A Rodríguez,Sonia Servitja,Adam D. Pfefferle,Jesús Herranz,Yuan Liu,Lisa A. Carey, Isabel Romero - Camarero,Rosalía Caballero,Charles M. Perou,Miguel Martín
Cancer Researchno. 9_Supplement (2024): PO1-15
Yao Li,Sarah C. Van Alsten, Dong Neuck Lee,Taebin Kim,Benjamin C. Calhoun,Charles M. Perou,Sara E. Wobker,J. S. Marron, Katherine A. Hoadley,Melissa A. Troester
Tomás Pascual,Aranzazu Fernandez-Martinez,Yash Agrawal,Adam D. Pfefferle,Nuria Chic,Fara Brasó-Maristany,Blanca Gonzàlez-Farré,Laia Paré,Guillermo Villacampa,Cristina Saura,Cristina Hernando,Montserrat Muñoz,Patricia Galván,Xavier Gonzàlez-Farré,Mafalda Oliveira,Miguel Gil-Gil,Eva Ciruelos,Patricia Villagrasa,Joaquín Gavilá,Aleix Prat,Charles M. Perou
NPJ breast cancerno. 1 (2024)
Cancer Researchno. 9_Supplement (2024): PO4-19
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作者统计
#Papers: 991
#Citation: 163017
H-Index: 143
G-Index: 402
Sociability: 9
Diversity: 0
Activity: 9
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