We pursue four main lines of research. First, we investigate the role of Wnt signaling in cell cycle regulation, notably mitosis. We found that Wnt signaling affects cell division by a novel posttranscriptional pathway and we are identifying the relevant Wnt target proteins. Second, we study the role and biochemical mechanism of signaling of Rspondins, stem cell growth factors, which we had previously discovered as Wnt signaling agonists. Third, we investigate the role of RNA helicases in protein kinase regulation in the context of Wnt signaling. Fourth, we screen for- novel Wnt pathway components and characterize them.