Professor Calogero Caruso MD is an immunopathologist whose research interests are in Biogerontology, in particular in genotypic and phenotypic determinants involved in attainment of successful and unsuccessful ageing. In this field, his group was the first to demonstrate the role of cytokine anti-inflammatory genotype in achieving longevity, turning the attention of the related scientific community towards the opposite role of inflammatory mediator genotypes in longevity and age-related diseases, including Alzheimer’s disease. He is currently Full Professor of General Pathology and Director of Palermo University Medical School “Ippocrate”. As previously stated, his laboratory studies several aspects of ageing, in particular the role of B immunosenescence and immunogenetics in longevity (the model of centenarians and of their offspring) and Alzheimer’s diseases (the role of systemic inflammation and diet).