My research has focused on novel technologies for disease diagnosis and treatment and has spanned from early innovation through development and validation and into clinical applications. Instruments that I have invented and developed have been applied in clinical studies of cervical cancer, bladder cancer, coronary atherosclerosis, laryngeal pathology, dermatologic lesions, colonic and esophageal cancer, and diseases of the common bile duct and pancreas. Since my years as a post-doctoral fellow and research scientist at MIT, I have focused a sustained effort toward the development of optical coherence tomography (OCT) and I am internationally recognized for important contributions that have made this technology a clinical reality. My specific contributions in this area include the invention of many of the core component technologies that are now in widespread use, the first clinical demonstrations of OCT in numerous clinical applications, and the validation of OCT protocols for, in particular, the diagnosis of esophageal cancer and its precursors and the detection and characterization of coronary artery pathology.