Keller is widely recognized for his research into the development of three-dimensional tissues for heart repair and regeneration. He also is interested in using telemedicine and computer technology for screening, monitoring and treatment of children in remote locations–which may ultimately result in beneficial advances for children in rural parts of Kentucky. He is the U.S. Medical Director for Touching Hearts in Tibet, a survey and treatment program for children in Tibet, operated by South East Asia Prayer Center. Keller is an active clinician locally as well, providing general pediatric cardiology services to patients with congenital heart disease.

Keller’s appointment was made possible as part of Kosair Charities‘ $5 million leadership commitment to the Kosair Charities Pediatric Heart Research Center at the Cardiovascular Innovation Institute, as well as support from the Children’s Hospital Foundation, Pediatric Cardiology Associates, PSC, the University of Louisville and the UofL Department of Pediatrics. The pediatric heart research center focuses on assessing and developing better heart assist devices for children.