The Kornum Lab studies sleep-wake neurophysiology with focus on the hypocretin (hcrt, also called orexin) system. We study how these neurons are affected by the immune system not only in narcolepsy but during sickness in general. We leverage single cell technology, animal disease models and human genetics to explore and discover how hcrt neurons and surrounding cells, networks and pathways are involved in the disease mechanisms of sickness behavior and sleep disorders.