Throughout his distinguished career, Dr. Celli has been a Principal Investigator or Co-Investigator of many groundbreaking research studies examining biomarkers in COPD, comparing the effectiveness of various respiratory therapies and examining the impact of specific drug regimens on COPD outcomes. Throughout the years, his research has been funded by the National Institutes of Health, various foundations, and multiple industry partners. Among his innovative works are the development of two indices to improve COPD clinical care including the BODE index which helps evaluate mortality risk in COPD patients and the COTE index which measures COPD Co-morbidity severity.