Dr. Rypma’s research is aimed at exploring the cognitive and neurobiological mechanisms of human memory and how those mechanisms are affected by aging and disease. He uses functional magnetic resonance imaging (fMRI) to observe the activity of younger and older adults as they perform cognitive tasks. fMRI is still a relatively new method for studying brain activity and much work remains to be done to perfect it, especially when comparing different populations like young and old. Thus, one focus of Dr. Rypma’s work has been the development of fMRI experimental methods to facilitate cross-population comparisons of neural activity.