Research Disciplines Biophysics, Cardiovascular Biology, Physiology Research Interests Novel signal transduction pathways in smooth muscles that regulate contractility and impact diseases of the vasculature, airway and gastrointestinal tract. Research Description Our goal is to identify and characterize the function of molecules participating in signal transduction pathways that modulate contractility of smooth muscle (SM) both in adult tissues and smooth muscle cells that migrate.We continue our long term interests in the basic properties of the contractile apparatus and myosin crossbridges that reflect the special SM phenotype.