基本信息
浏览量:4
职业迁徙
个人简介
Research
The research program pursued by Antonio Iavarone seeks to unravel the biologic and genetic alterations driving subgroups of malignant brain tumors and exploit this information for rational therapeutic stratification. The Iavarone group identified master regulators of cancer initiation and progression in distinct sub-groups of brain tumors. They discovered the first example of oncogenic and tumor addicting gene fusions in glioblastoma (FGFR3-TACC3) and reported that FGFR3-TACC3 fusions trigger tumorigenesis through activation of oxidative phosphorylation. These fusions are among the most frequent chromosomal translocations across all types of human cancer and the FDA approved the targeting of these chromosomal translocations with FGFR inhibitors. Antonio Iavarone chaired the Pan-Glioma ATLAS-TCGA Working Group and the Neurofibromatosis 1 synodos that united international researchers to formulate guidelines for accurate diagnosis and prognosis of glioma patients. By using all the computational and experimental tools at disposal, they combine innovations in both areas to continue making transformative mechanistic discoveries and provide personalized therapeutics to increasing number of patients with deadly tumor types.
The research program pursued by Antonio Iavarone seeks to unravel the biologic and genetic alterations driving subgroups of malignant brain tumors and exploit this information for rational therapeutic stratification. The Iavarone group identified master regulators of cancer initiation and progression in distinct sub-groups of brain tumors. They discovered the first example of oncogenic and tumor addicting gene fusions in glioblastoma (FGFR3-TACC3) and reported that FGFR3-TACC3 fusions trigger tumorigenesis through activation of oxidative phosphorylation. These fusions are among the most frequent chromosomal translocations across all types of human cancer and the FDA approved the targeting of these chromosomal translocations with FGFR inhibitors. Antonio Iavarone chaired the Pan-Glioma ATLAS-TCGA Working Group and the Neurofibromatosis 1 synodos that united international researchers to formulate guidelines for accurate diagnosis and prognosis of glioma patients. By using all the computational and experimental tools at disposal, they combine innovations in both areas to continue making transformative mechanistic discoveries and provide personalized therapeutics to increasing number of patients with deadly tumor types.
研究兴趣
论文共 231 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Cellno. 5 (2024): 1255-1277.e27
Tathiane M. Malta,Thais S. Sabedot, Natalia S. Morosini,Indrani Datta,Luciano Garofano,Wies Vallentgoed,Frederick S. Varn,Kenneth Aldape, Fulvio D'Angelo,Spyridon Bakas,Jill S. Barnholtz-Sloan,Hui K. Gan,
CANCER RESEARCHno. 5 (2024): 741-756
Neuro-oncology practiceno. 2 (2024): 142-149
Alberto Picca, Anna Luisa Di Stefano,Julien Savatovsky,François Ducray,Olivier Chinot, Elisabeth Cohen-Jonathan Moyal,Paule Augereau,Emilie Le Rhun,Yohann Schmitt, Nabila Rousseaux, Ariane Murielle Mbekwe Yepnang, Candice Estellat,
Neuro-oncology advancesno. 1 (2024): vdae068-vdae068
Lujia Wang, Hairong Wang, Fulvio D'Angelo,Lee Curtin,Christopher P. Sereduk,Gustavo De Leon,Kyle W. Singleton,Javier Urcuyo,Andrea Hawkins-Daarud,Pamela R. Jackson,Chandan Krishna,Richard S. Zimmerman,
NEURO-ONCOLOGY PRACTICEno. 2 (2024): 142-149
Cancer cellno. 3 (2024): 358-377.e8
Luciano Garofano, Fulvio D'Angelo, Michael Oh, Michele Ceccarelli,Franck Bielle,Marc Sanson,Anna Lasorella,Antonio Iavarone
Cancer Researchno. 6_Supplement (2024): 6938-6938
NEURO-ONCOLOGY (2024)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn