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个人简介
In 1994, Dr. Wynshaw-Boris set up an independent laboratory at the National Human Genome Research Institute of the NIH, where he initiated a program using mouse models to study human genetic diseases, with a focus on neurogenetic diseases. In 1999, he moved to UCSD School of Medicine, where he became Professor of Pediatrics and Medicine, as well as Chief of the Division of Medical Genetics in the Department of Pediatrics. In 2007, he moved to UCSF School of Medicine, where he was the Charles J. Epstein Professor of Human Genetics and Pediatrics, and the Chief of the Division of Medical Genetics in the Department of Pediatrics. In June 2013, he returned to Cleveland to become the Chair of the Department of Genetics and Genome Sciences.
Research Projects
Research in Dr. Wynshaw-Boris's laboratory is focused on understanding genetic and biochemical pathways important for the development and function of the mammalian central nervous system, primarily using mouse models and more recently induced pluripotent stem cells (iPSCs) of human and mammalian diseases to define pathways disrupted in these diseases.
There are currently four main projects in the laboratory: the role of the three mouse Dishevelled genes during early development; the genetics and pathophysiology of autism and social behavior, with particular emphasis on pathways responsible for brain overgrowth; human iPSC models of microcephaly and early neurodegeneration caused by mutations in DNA repair and checkpoint genes; and finally the development of a novel concept called Chromosome Therapy, based on the correction of large chromosome aberrations by ring chromosome induction in patient-derived iPSCs.
Research Projects
Research in Dr. Wynshaw-Boris's laboratory is focused on understanding genetic and biochemical pathways important for the development and function of the mammalian central nervous system, primarily using mouse models and more recently induced pluripotent stem cells (iPSCs) of human and mammalian diseases to define pathways disrupted in these diseases.
There are currently four main projects in the laboratory: the role of the three mouse Dishevelled genes during early development; the genetics and pathophysiology of autism and social behavior, with particular emphasis on pathways responsible for brain overgrowth; human iPSC models of microcephaly and early neurodegeneration caused by mutations in DNA repair and checkpoint genes; and finally the development of a novel concept called Chromosome Therapy, based on the correction of large chromosome aberrations by ring chromosome induction in patient-derived iPSCs.
研究兴趣
论文共 304 篇作者统计合作学者相似作者
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crossref(2023)
Kazuhito Toyo-oka,Timothy J. Bowen,Shinji Hirotsune,Zirong Li, Sonia Jain,Sara Ota, Laure Escoubet Lozach, Ivan Garcia Bassett,Jean Lozach, Michael G. Rosenfeld,Christopher K. Glass,Robert Eisenman,
crossref(2023)
bioRxiv : the preprint server for biology (2023)
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crossref(2023)
Sheetal Sreeram,Konstantin Leskov, Yoelvis Garcia Mesa,Fengchun Ye, Ya Chen, Luke Bury,Anthony Wynshaw-Boris,Jonathan Karn
JOURNAL OF NEUROVIROLOGY (2023): S31-S31
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Elizabeth Buttermore,Stormy Chamberlain,Jannine Cody,Gregory Costain,Louis Dang, Andrew DeWoody,Yssa DeWoody, Kira Dies,Evan Eichler,Santhosh Girirajan,Marie Gramm, Alycia Halladay,
AMERICAN JOURNAL OF HUMAN GENETICSno. 8 (2022): 1353-1365
Jagjit Singh,Noah J. Daniels, Filomena Pirozzi,Anthony Wynshaw-Boris, Rodrigo Lopez-Gonzalez,Richard A. Padgett
biorxiv(2022)
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