The fields of study he is best known for:
Gene
Enzyme
Signal transduction
Anthony J. Koleske focuses on Cell biology, Transcription factor II D, RNA polymerase II, General transcription factor and Tyrosine kinase. His studies in Cell biology integrate themes in fields like Cortactin and Cytoskeleton. His research integrates issues of Molecular biology, Transcription factor II F and RNA polymerase II holoenzyme in his study of Transcription factor II D.

The various areas that Anthony J. Koleske examines in his RNA polymerase II holoenzyme study include RNA polymerase I and Sigma factor. His work deals with themes such as Ubiquitin ligase and Phosphorylation, which intersect with Tyrosine kinase. His studies deal with areas such as Invadopodia and Invadopodium as well as Phosphorylation.