We aim to gain a deeper understanding of how the components of gene delivery formulations interact with the immune system in order to improve the potency and enable clinical translation. We use a variety of biochemical assays, RNA formulation approaches, nanoparticle characterization methods, imaging platforms and cell culture, human explant and animal models for our research.

Research Area
Gene delivery has the potential to prevent or cure most diseases, but the main barrier is delivering enough nucleic acid to the target cells or tissues. We seek to gain a deeper understanding of how the components of gene delivery formulations interact with the immune system in order to improve potency and enable clinical translation. We use a variety of biochemical assays, RNA formulation strategies, nanoparticle characterization methods, imaging techniques, culture of cells and tissues, small and large animal models to pursue our research interests.