One of the main topics of our research is the structure and function of proteins which bind to the two ends of microtubules, the plus- and the minus-end. We are interested in biochemical activities and functions of microtubule plus-end tracking proteins (+TIPs) – factors that associate specifically with the growing microtubule ends, regulate microtubule dynamics and their interactions with various cellular structures, such as the actin cytoskeleton, focal adhesions and cell-cell contacts. We study how +TIPs help cells to polarise and move or form specialised microtubule-based structures such as cilia and centrioles. We are also investigating the proteins that specifically target and organise microtubule minus ends. We try to understand how minus-end targeting proteins control the geometry of microtubule networks in differentiated cells, such as epithelial and muscle cells.