Dr. De Marzo has published more than 320 papers, reviews and book chapters, and, he and colleagues described a potential new prostate cancer precursor/risk factor lesion for prostate cancer, proliferative inflammatory atrophy. His laboratory continues to study the role of inflammation in prostate carcinogenesis as well as the role of the MYC oncogene and the PTEN tumor suppressor in prostate cancer early disease development and progression. Along with colleagues, his lab is also heavily engaged in genomic studies of early prostate cancer and precursor lesions.
In addition, his lab also has a number of ongoing translational research efforts focused largely on using immunohistochemistry against PTEN and other biomarkers, where such markers might aid in diagnosis, prognosis, treatment stratification and disease resistance monitoring. Recently, his lab has also been performing extensive studies using multiplex immunofluorescence staining for inflammatory and other cell types, in situ hybridization for a number of different nucleic acid targets, as well as biospecimen science investigations related to optimizing methods of tissue handling for molecular studies.