基本信息
浏览量:158
职业迁徙
个人简介
My background is in molecular and cellular immunology research, with emphasis on MHC molecular genetics (1979-1984), peripheral T cell tolerance (1984-1997) and T cell regulation mediated by the enzyme indoleamine 2,3 dioxygenase, IDO (1997-present). In 1998 we reported that IDO regulates T cell immunity, establishing a novel paradigm in understanding how T cell regulation occurs at sites of inflammation. This finding led to new immunotherapies to treat cancer and infections and to protect healthy tissues from immune-mediated destruction by manipulating IDO. Based on our research, a proprietary IDO inhibitor is under scrutiny in Phase II trials as a potential immune checkpoint blockade inhibitor in cancer patients. My research objectives are to elucidate how IDO contributes to inflammatory and immunologic processes that promote or alleviate disease in mouse models of cancer, infectious and autoimmune diseases and transplantation. Current research goals are to evaluate the role of DNA sensing pathways in regulating autoimmunity and promoting tumorigenesis, developing novel immunotherapies by manipulating IDO, and elucidating how IDO enhances pain, a common co-morbidity associated with many inflammatory syndromes of clinical importance
研究兴趣
论文共 389 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Rui Chen, Elena Lukianova,Ina Schim van der Loeff,Jarmila Stremenova Spegarova,Joseph D. P. Willet,Kieran D. James,Edward J. Ryder,Helen Griffin,Hanna Ijspeert,Akshada Gajbhiye,Frederic Lamoliatte,Jose L. Marin-Rubio,Lisa Woodbine,Henrique Lemos,David J. Swan, Valeria Pintar, Kamal Sayes,Elias R. Ruiz-Morales, Simon Eastham,David Dixon,Martin Prete,Elena Prigmore,Penny Jeggo,Joan Boyes,Andrew Mellor,Lei Huang,Mirjam van der Burg, Karin R. Engelhardt,Asbjorg Stray-Pedersen,Hans Christian Erichsen,Andrew R. Gennery,Matthias Trost,David J. Adams,Graham Anderson,Anna Lorenc,Gosia Trynka,Sophie Hambleton
Science Immunologyno. 95 (2024)
crossref(2023)
crossref(2023)
crossref(2023)
crossref(2023)
crossref(2023)
crossref(2023)
crossref(2023)
加载更多
作者统计
#Papers: 389
#Citation: 39413
H-Index: 87
G-Index: 195
Sociability: 7
Diversity: 0
Activity: 1
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn