基本信息
浏览量:3
职业迁徙
个人简介
Research Interests
Our long term goal is to use an integrated approach, combining developmental genetics, cell biology, genomics and mathematical modeling to understand how organisms evolve to changes in the environment. Our main model system is the nematode, which offer many advantages for this integrative approach. We have been studying some non-Caenorhabditis nematode species that have many features not present in C. elegans, but that are useful as models for fundamental biological phenomena:
Developmental basis for aging: We are studying a species of nematode that produces genetically identical genders with distinct lifespans; this model allows intra-specific comparisons in which no genetic or environmental confounding effects are present. The nematode can be used to model more complex organisms that include humans because recent work revealed that genes modulating aging are highly conserved in evolution.
Cross-generational inheritance: Epigenetic inheritance across generations is relatively widespread in living organisms. However, in many cases it is unclear how stimuli experienced by one generation is passed to following generations. We are studying a species of nematode in which the gender of the progeny depends on environmental cues experienced by the mother. We are studying the mechanisms of this mode of inheritance.
Asymmetric cell division: Some of the cellular diversity during development is generated by asymmetric cell divisions. We are using a nematode model in which two kinds of sperm are generated by an asymmetric cell division (Shakes et al, 2011). Because the progeny of each kind of sperm is easily identifiable, we are using this nematode to find the cellular and genetic basis of asymmetric cell division.
研究兴趣
论文共 53 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Frontiers in aging (2024): 1380016-1380016
Reference Module in Biomedical Sciences (2024)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Journal of nematologyno. 1 (2023): 20220059-20220059
Figshare (2023)
Chaweewan Sirakawin,Dongfa Lin,Ziyue Zhou,Xiaoxin Wang, Rhianne Kelleher,Shangyuan Huang,Weimiao Long,Andre Pires-daSilva,Yu Liu,Jingjing Wang,Ilya A. Vinnikov
Aging Cellno. 3 (2023)
Scientific Reportsno. 1 (2022)
加载更多
作者统计
#Papers: 53
#Citation: 2509
H-Index: 21
G-Index: 50
Sociability: 5
Diversity: 0
Activity: 0
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn