My focus has been in the development and application of novel methods for understanding the basis of inherited predisposition to cancer and other complex diseases. I developed design criteria for the conduct of genetics studies and subsequently applied these for studying families and for population based analysis. I colead the international Genetic Associations and Mechanisms in Oncology (GAME-ON) consortium which brings together population-based researchers studying genetic and environmental causes of lung, breast, prostate, colon and ovarian cancers.