Ambreen Sayed-Zahid - Voyager Therapeut, Cambridge, MA USA

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论文共 9 篇作者统计合作学者相似作者

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Highly conserved brain vascular receptor ALPL mediates transport of engineered viral vectors across the blood-brain barrier

Tyler C. Moyer, Brett A. Hoffman, Weitong Chen, Ishan Shah,Xiao-Qin Ren,Tatiana Knox,Jiachen Liu, Wei Wang,Jiangyu Li, Hamza Khalid,Anupriya S. Kulkarni, Munachiso Egbuchulam,Joseph Clement, Alexis Bloedel,Matthew Child,Rupinderjit Kaur, Emily Rouse, Kristin Graham,Damien Maura,Zachary Thorpe,Ambreen Sayed-Zahid,Charlotte Hiu-Yan Chung,Alexander Kutchin,Amy Johnson,Johnny Yao,Jeffrey Thompson,Nilesh Pande,Mathieu E. Nonnenmacher

biorxiv（2024）

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Stepwise Evolution of the AAV5-Derived Capsid VCAP-100 Identifies Novel Variants with Improved CNS Transduction and Liver Detargeting Following Systemic Injection

Damien Maura,Jennifer C. Yu,Matthew Child, Roop Kaur,Zachary Thorpe,Xiaoqin Ren, Netsanet Gebremedhin,Jiangyu Li,Jiachen Liu,Timothy Fiore,Dillon Kavanagh, Alexander Kubiak,Kyle Grant,Ambreen Sayed-Zahid,Tyler Moyer, Kristin P. Graham,Alexander Kutchin,Johnny Yao, Todd A. Carter,Mathieu E. Nonnenmacher

MOLECULAR THERAPY（2023）

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Directed Evolution of an AAV9 Library Identifies a Capsid Variant with Enhanced Brain Tropism and Liver De-Targeting in Non-Human Primates and Mice Following Systemic Administration

Tyler Moyer, Kristin Graham,Jiachen Liu,Xiaoqin Ren,Joseph Clement, Alexis Bloedel,Anupriya Kulkarni, Kailyn Looby, Hamza Khalid,Bruce Amy, Chiso Egbuchulam,Dan Laks,Matthew Child,Rupinderjit Kaur,Ambreen Sayed-Zahid, Michael Grannan,Charlotte Chung,Tatiana Knox, Brett Hoffman,Alex Kutchin,Amy Johnson, Andrew Cameron,Kyle Grant,Johnny Yao,Nilesh Pande,Jeff Thompson,Garrett Heffner, Todd A. Carter,Mathieu E. Nonnenmacher

MOLECULAR THERAPYno. 4 (2023): 57-57

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An Evolved AAV Variant with Enhanced Brain and Spinal Cord Tropism and Translation across Primate Species

Jing Lin,Charlotte Chung,Jeff Thompson,Kyle Grant,Timothy Fiore,Damien Maura,Johnny Yao,Ambreen Sayed-Zahid,Amy Johnson, Wei Wang,Shaoyong Li,Nilesh Pande,Anupriya Kulkarni,Matthew Child,Rupinderjit Kaur,Zachary Thorpe,Xiaoqin Ren,Hongxing Wang,Mathieu E. Nonnenmacher

MOLECULAR THERAPYno. 4 (2023): 658-658

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Directed Evolution of an AAV5 Capsid Library Identifies a Variant with Enhanced Transduction in Non-Human Primate and Rodent Brain Following Systemic Administration

Mathieu E. Nonnenmacher,Amy Z. Ren,Wei Wang,Matthew A. Child,Xiao-Qin Ren,Katherine Tyson,Jessenia Laguna-Torres,Anupriya Kulkarni,Nilesh Pande,Ambreen Sayed-Zahid,Charlotte H. Y. Chung,Michael Hefferan,Tyler Moyer,Damien Maura

MOLECULAR THERAPY（2022）

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Characterization of a Novel AAV Gene Replacement Therapy, VY-NPC101, In Vitro and In Vivo for the Treatment of Niemann-Pick Disease Type C1

Elisabeth R. Knoll,Jenna Tocci,Brian Ezell, Eric Liu,Ambreen Sayed-Zahid, Mingwei Li,Holger Patzke,Todd Carter,Kelly Bales, Jeffrey Brown, Heather Yonutas

MOLECULAR THERAPY（2022）

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Intravenous Delivery of AAV Gene Therapy Provides Broad SOD1 Knockdown in the Spinal Cord and Robust Efficacy in a Mouse Model of SOD1-ALS

Michael D. Grannan,Ambreen Sayed-Zahid,Michael Hefferan,Mathieu Nonnenmacher, Shaoyong Li Kyle Grant,Nilesh Pande,Katherine Tyson,Jessenia Laguna-Torres,Anupriya Kulkarni, James Kaufman,Joe Clement,Jeffrey Thompson,Dinah W. Y. Sah,Holger Patzke

MOLECULAR THERAPY（2022）

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Directed Evolution of AAV9 Peptide Display Libraries Identifies a Family of Cross-Species Variants with Enhanced Brain Tropism in Non-Human Primates and Mice Following Systemic Administration

Tyler Moyer,Jiangyu Li,Dan R. Laks,Matthew A. Child,Katherine Tyson,Rupinderjit Kaur,Xiao-Qin Ren,Ambreen Sayed-Zahid, Michael Grannon,Charlotte Hiu-Yan Chung,Nilesh Pande,Jeff Thompson,Wei Wang, Samuel Hasson,Michael Hefferan,Mathieu Nonnenmacher

MOLECULAR THERAPY（2022）

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Development of AAV-GBA1 Gene Replacement Therapy for IV Delivery via Blood Brain Barrier Penetrant AAV Capsid

Charlotte Chung,Giri Murlidharan,Smita Jagtap,Adewale Adeluyi,Elisabeth Knoll,Abigail Ecker,Brian Ezell,Tatiana Athanasopoulos, Brett Hoffman,Tatiana Knox,Jenna Tocci,Emalee Peterson,Ambreen Sayed-Zahid,Maneesha Paranjpe,Kyle Grant,Kelly Bales,Todd Carter

MOLECULAR THERAPY（2022）

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