My research interests focus on the development of state of the art methodologies in mass spectrometry for use in advancing our global knowledge of human biology, specifically the dynamic, epigenetic modulation and regulation of the proteome. This occurs in the context of deciphering molecular alterations and defects that underlie disease and cancer.

Some specific projects include research on the mammalian and human proteomes including large macromolecular assemblages that are dynamic, functional entities in cells. These include the signal processing protein machine, a pseudo-organelle called the postsynaptic density, and RNA/protein complexes such as the spliceosome. In addition, we study the nature and role of posttranslational modulation in cell biology including protein complexes in signaling networks such as ras, p53, and chromatin biology including DNA damage sensing.