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Career Trajectory
Bio
Alice started her scientific research career at The University of Manchester (UK), where she undertook a PhD in Molecular Genetics and Cell Biology investigating the role of bestrophin-1 in ocular disease. Her doctoral studies made a significant contribution to the field by elucidating underlying disease mechanisms, deciphering phenotype-genotype correlations and expanding the phenotypic spectrum of diseases. Her first postdoctoral position, at UCL Institute of Ophthalmology (IoO) UK, focused on identifying novel genetic causes of autosomal recessive retinal diseases by exploiting homozygosity mapping of consanguineous pedigrees and new developments in next generation sequencing methods. Alice’s research contributed to the identification of 6 novel genetic causes of ocular conditions including Leber’s congenital amaurosis, benign fleck retina and retinitis pigmentosa.
Alice subsequently undertook a second postdoctoral position at UCL IoO investigating the genetics of complex and monogenic corneal diseases, investigating a diverse range of conditions including keratoconus, X-linked megalocornea, epithelial recurrent erosion dystrophy and TGFBI-associated dystrophies. She developed a special interest in the genetic causes and molecular mechanisms underlying inherited corneal endothelial dystrophies (CEDs), and was awarded a Fight for Sight Early Career Investigator fellowship in 2015 to initiate her own independent research program at UCL IoO to focus on this area. Currently, her research program aims to understand the genetic origins of this disease group, which ranges from dominant polymorphous corneal dystrophy (PPCD) to the more common age-related condition Fuchs corneal endothelial dystrophy (FECD). She translates her genetic discoveries to understanding the pathophysiology of CEDs and developing novel diagnostic approaches and therapeutic strategies for patients with CEDs.
Alice subsequently undertook a second postdoctoral position at UCL IoO investigating the genetics of complex and monogenic corneal diseases, investigating a diverse range of conditions including keratoconus, X-linked megalocornea, epithelial recurrent erosion dystrophy and TGFBI-associated dystrophies. She developed a special interest in the genetic causes and molecular mechanisms underlying inherited corneal endothelial dystrophies (CEDs), and was awarded a Fight for Sight Early Career Investigator fellowship in 2015 to initiate her own independent research program at UCL IoO to focus on this area. Currently, her research program aims to understand the genetic origins of this disease group, which ranges from dominant polymorphous corneal dystrophy (PPCD) to the more common age-related condition Fuchs corneal endothelial dystrophy (FECD). She translates her genetic discoveries to understanding the pathophysiology of CEDs and developing novel diagnostic approaches and therapeutic strategies for patients with CEDs.
Research Interests
Papers共 92 篇Author StatisticsCo-AuthorSimilar Experts
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Freddie L. Braddock,Jessica C. Gardner,Nihar Bhattacharyya,Beatriz Sanchez-Pintado, Marcos Costa,Christina Zarouchlioti,Anita Szabo,Petra Liskova,Michael E. Cheetham, Robert D. Young,Caroline Thaung,Alice E. Davidson,Stephen J. Tuft,Alison J. Hardcastle
European journal of human genetics EJHGno. 12 (2024): 1583-1589
Marcos Abreu Costa,Anita Szabo,Nihar Bhattacharyya,Christina Zarouchlioti, Nathaniel Hafford-Tear,Amanda Sadan, Muhammad Moghul,Kirithika Muthusamy,Pavlina Skalicka,Petra Liskova,Stephen Tuft, Alison J. Hardcastle,Nikolas Pontikos,Alice Davidson
EUROPEAN JOURNAL OF HUMAN GENETICS (2024): 373-374
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Siyin Liu,Amanda N. Sadan,Nihar Bhattacharyya,Christina Zarouchlioti,Anita Szabo, Marcos Abreu Costa,Nathaniel J. Hafford-Tear,Anne-Marie S. Kladny,Lubica Dudakova,Marc Ciosi,Ismail Moghul,Mark R. Wilkins,Bruce Allan,Pavlina Skalicka,Alison J. Hardcastle,Nikolas Pontikos,Catey Bunce,Darren G. Monckton,Kirithika Muthusamy,Petra Liskova,Stephen J. Tuft,Alice E. Davidson
medrxiv(2024)
Anita Szabo,Christina Zarouchlioti,Nihar Bhattacharyya,Amanda Sadan, Nathaniel Hafford-Tear,Pavlina Skalicka,Jana Moravikova, Anthony Khawaja, Alison J. Hardcastle,Kirithika Muthusamy, Petra Liskova,Stephen Tuft,Pirro Hysi,Nikolas Pontikos,Alice Davidson
EUROPEAN JOURNAL OF HUMAN GENETICS (2024): 791-791
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Nihar Bhattacharyya,Niuzheng Chai,Nathaniel J. Hafford-Tear,Amanda N. Sadan,Anita Szabo,Christina Zarouchlioti,Jana Jedlickova,Szi Kay Leung, Tianyi Liao,Lubica Dudakova,Pavlina Skalicka,Mohit Parekh,Ismail Moghul,Aaron R. Jeffries,Michael E. Cheetham,Kirithika Muthusamy,Alison J. Hardcastle,Nikolas Pontikos,Petra Liskova,Stephen J. Tuft,Alice E. Davidson
PLOS GENETICSno. 5 (2024)
Karynne Patterson,Jessica x. Chong,Doug d. Chung,Walter Lisch,Carol l. Karp, Erling Dreisler,David Lockington,Jens m. Rohrbach,Dorota Garczarczyk-asim,Thomas Mueller,Stephen j. Tuft,Pavlina Skalicka,Yael Wilnai,Nadra naser Samra, Ali Ibrahim, Hanna Mandel,Alice e. Davidson,Petra Liskova,Anthony j. Aldave,Michael j. Bamshad,Andreas r. Janecke
AMERICAN JOURNAL OF OPHTHALMOLOGY (2024): 183-195
Christina Zarouchlioti,Stephanie Efthymiou,Stefano Facchini,Natalia Dominik,Nihar Bhattacharyya,Siyin Liu, Marcos Abreu Costa,Anita Szabo,Amanda N. Sadan,Albert S. Jun,Enrico Bugiardini,Henry Houlden,Andrea Cortese,Pavlina Skalicka,Lubica Dudakova,Kirithika Muthusamy,Michael E. Cheetham,Alison J. Hardcastle,Petra Liskova,Stephen J. Tuft,Alice E. Davidson
EBIOMEDICINE (2024)
Nikolas Pontikos,William Woof,Miriam Bauwens,Saoud Al-Khuzaei,Behnam Javanmardi,Michalis Georgiou,Malena Daich Varela,Thales Antonio Cabral De Guimaraes, Muhammad Moghul,Alice Davidson, Panos Sergouniotis,Jamie Ellingford,Konstantinos Balaskas,Alison J. Hardcastle,Susan Downes,Gavin Arno,Peter Krawitz,Damian Smedley,Elfride De Baere,Andrew Webster,Michel Michaelides,Omar Mahroo
EUROPEAN JOURNAL OF HUMAN GENETICS (2024): 5-6
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Author Statistics
#Papers: 92
#Citation: 2428
H-Index: 27
G-Index: 48
Sociability: 6
Diversity: 3
Activity: 12
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