基本信息
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职业迁徙
个人简介
Our research project aims to tackle the problem of persistence and chronic infection by Pseudomonas aeruginosa. P. aeruginosa is a gram-negative bacterium found in various environments including soil, water and vegetation. Importantly it is an opportunistic human pathogen, responsible for numerous nosocomial infections in immuno-compromised patients. These infections are fatal in cystic fibrosis patients.
Our project follows several research lines, which deal with essential molecular mechanisms involved in biofilm formation and type VI protein secretion. These two key processes are co-regulated and highly relevant for P. aeruginosa pathogenesis. The regulatory control involves signalling pathways associated with two-component regulatory systems and the intracellular second messenger c-di-GMP. We address these questions using multi-disciplinary approaches in molecular microbiology, genetics, cellular microbiology, structural biology and biochemistry.
Our project follows several research lines, which deal with essential molecular mechanisms involved in biofilm formation and type VI protein secretion. These two key processes are co-regulated and highly relevant for P. aeruginosa pathogenesis. The regulatory control involves signalling pathways associated with two-component regulatory systems and the intracellular second messenger c-di-GMP. We address these questions using multi-disciplinary approaches in molecular microbiology, genetics, cellular microbiology, structural biology and biochemistry.
研究兴趣
论文共 305 篇作者统计合作学者相似作者
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引用量
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期刊级别
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合作机构
NATURE COMMUNICATIONSno. 1 (2024)
JOURNAL OF BIOLOGICAL CHEMISTRYno. 2 (2024)
PLOS pathogensno. 5 (2023): e1011428-e1011428
bioRxiv the preprint server for biology (2023)
Microbiology (Reading, England)no. 1 (2023)
RSC CHEMICAL BIOLOGYno. 1 (2023): 94-100
PLOS PATHOGENSno. 4 (2023)
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作者统计
#Papers: 306
#Citation: 14571
H-Index: 68
G-Index: 114
Sociability: 7
Diversity: 0
Activity: 1
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