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Dr. Takashima's major research interest is in the biology of DCs, which play crucial roles in the induction of both innate and adaptive immunity. His group has recently identified a new leukocyte population that exhibits the surface phenotypes and functional properties of both neutrophils and DCs. This population, termed “neutrophil-DC hybrid,” plays dual protective roles against bacterial infection by rapidly capturing and killing bacteria and presenting bacterial antigens to T cells. Interestingly, neutrophil-DC hybrids are derived from immature neutrophils and they emerge in lymphoid and non-lymphoid tissues under inflammatory conditions. Using recently developed, HTP-compatible assay platforms, his group has identified several cytokines and small chemical compounds capable of regulating neutrophil transdifferentiation into hybrid cells. Studies are in progress in his laboratory to define: a) mechanisms regulating generation and function of neutrophil-DC hybrids, b) contributions of hybrids to the pathogenesis of autoimmune inflammatory disease, allergic disorders, and cancer, and c) in vivo impact of the above cytokines and small compounds on the development of neutrophil-DC hybrids.
研究兴趣
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Jesse J. Veenstra,Heather M. Gibson, Peter J. Littrup, Joyce D. Reyes,Michael L. Cher,Akira Takashima,Wei-Zen Wei
crossref(2023)
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#Papers: 208
#Citation: 7251
H-Index: 47
G-Index: 80
Sociability: 6
Diversity: 0
Activity: 0
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