Supplemental Table 1. List of DNA gene mutations tested in diagnostic tumor samples of our ALL cohort.

Supplemental Table 2. List of 80 genes with RNA sequencing coverage.

Supplemental Table 3. Demographics of 400 adult ALL cases.

Supplemental Table 4. List of first-line (initial) therapies in Ph-positive B-ALL, Ph-negative B-ALL, and Tlineage ALL patients.

Supplemental Table 5. Baseline gene rearrangements and structural variants of 329 molecularly characterized adult B-ALL patients.

Supplemental Table 6. Baseline gene rearrangements and structural variants of 71 molecularly characterized adult T-lineage ALL patients.

Supplemental Table 7. List of pathogenic/likely pathogenic germline variants in our ALL cohort.

Supplementary Table 8. Multivariable analysis of overall survival (OS) in B-ALL patients.

Supplemental Table 9. Clinical characteristics of patients studied in scDNA + protein sequencing experiments.

Supplemental Table 10. Clinical characteristics of patients studied in scRNA-seq experiment.

Supplemental Table 11. Ingenuity pathway analysis comparing B-lymphoblasts from B-ALL with MyM vs B-ALL without MyM.