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My previous work demonstrated that specific immune cells, monocytes, in the blood of chronic hepatitis B patients internalize and retain viral antigen. Using a combination of cytokines we could stimulate presentation of the captured antigen to boost HBV-specific T cell immunity. The goal now is to further understand this mechanism in patients to define an immunotherapeutic drug combination that can be used to restore anti-viral T cell immunity using the personalized antigen reservoir in the patients’ blood.
Our research on human liver immunology focuses on how age, sex and infection impact the intrahepatic immune response. Chronic hepatitis B is a progressive disease that worsens with age and men are more likely than women to develop liver cancer. We are trying to elucidate functional differences in the liver to understand HBV progression and biomarkers that could provide a drug targets to stop or slow disease progression.
Our research on human liver immunology focuses on how age, sex and infection impact the intrahepatic immune response. Chronic hepatitis B is a progressive disease that worsens with age and men are more likely than women to develop liver cancer. We are trying to elucidate functional differences in the liver to understand HBV progression and biomarkers that could provide a drug targets to stop or slow disease progression.
Research Interests
Papers共 153 篇Author StatisticsCo-AuthorSimilar Experts
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EUROPEAN JOURNAL OF IMMUNOLOGY (2024)
Sergi Clotet-Freixas,Olga Zaslaver,Max Kotlyar,Chiara Pastrello,Andrew T. Quaile,Caitriona M. McEvoy,Aninda D. Saha,Sofia Farkona,Alex Boshart, Katarina Zorcic, Slaghaniya Neupane,Kieran Manion, Maya Allen, Michael Chan,Xuqi Chen,Arthur P. Arnold,Peggy Sekula,Inga Steinbrenner,Anna Koettgen,Allison B. Dart,Brandy Wicklow,Jon M. McGavock,Tom D. Blydt-Hansen,Clara Barrios,Marta Riera,Maria J. Soler, Amandine Isenbrandt,Jerome Lamontagne-Proulx,Solene Pradeloux,Katherine Coulombe,Denis Soulet,Shravanthi Rajasekar,Boyang Zhang,Rohan John,Aman Mehrotra,Adam Gehring,Maija Puhka,Igor Jurisica,Minna Woo,James W. Scholey,Hannes Rost,Ana Konvalinka
Adriana Migliorini,Sabrina Ge,Michael H Atkins,Amanda Oakie,Rangarajan Sambathkumar, Gregory Kent, Haiyang Huang, Angel Sing,Conan Chua,Adam J Gehring,Gordon M Keller,Faiyaz Notta,Maria Cristina Nostro
Cell stem cellno. 11 (2024): 1591-1611.e8
biorxiv(2024)
Antiviral Researchpp.105893-105893, (2024)
Miriam Bosch,Nina Kallin,Sainitin Donakonda,Jitao David Zhang,Hannah Wintersteller,Silke Hegenbarth,Kathrin Heim,Carlos Ramirez, Anna Fuerst, Elias Isaac Lattouf,Martin Feuerherd, Sutirtha Chattopadhyay,Nadine Kumpesa,Vera Griesser,Jean-Christophe Hoflack,Juliane Siebourg-Polster,Carolin Mogler,Leo Swadling,Laura J. Pallett,Philippa Meiser,Katrin Manske,Gustavo P. de Almeida,Anna D. Kosinska,Ioana Sandu,Annika Schneider, Vincent Steinbacher, Yan Teng,Julia Schnabel, Fabian Theis,Adam J. Gehring,Andre Boonstra,Harry L. A. Janssen,Michiel Vandenbosch,Eva Cuypers,Rupert Oellinger,Thomas Engleitner,Roland Rad,Katja Steiger,Annette Oxenius,Wan-Lin Lo,Victoria Klepsch,Gottfried Baier,Bernhard Holzmann,Mala K. Maini,Ron Heeren,Peter J. Murray,Robert Thimme, Carl Herrmann,Ulrike Protzer,Jan P. Boettcher,Dietmar Zehn,Dirk Wohlleber,Georg M. Lauer,Maike Hofmann,Souphalone Luangsay,Percy A. Knolle
JOURNAL OF INFECTIOUS DISEASES (2024)
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Author Statistics
#Papers: 155
#Citation: 5607
H-Index: 37
G-Index: 74
Sociability: 7
Diversity: 3
Activity: 89
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