A major focus of Dr. Szpiro's research is developing statistical methods for environmental epidemiology and applying these methods to studies of air pollution in major cohort studies such as MESA Air, the NIEHS Sisters Study, and the Women's Health Initiative. Current methodological projects include spatio-temporal exposure modeling, measurement error correction, optimal exposure prediction modeling for health effect inference, dimension reduction for spatially misaligned data, and control for unmeasured spatial and/or temporal confounding.