Initially, her lab focused on regulation of the biosynthesis and assembly of sodium pump subunits and molecular mechanisms controlling sodium pump isoforms in kidney, cardiac and skeletal muscle by potassium, hormones, and other factors under normal conditions and during human heart failure. Building on these findings, the lab addressed the coordinated and concerted control of extracellular potassium by skeletal muscle, kidney and gut in response to altered metabolic and electrolyte demands and have begun to use these findings to address the mechanisms responsible for the cardiovascular benefit of raising dietary K/Na ratio.